A position for a postdoctoral fellow is available in the laboratory of Dr. Masaoki Kawasumi (Assistant Professor, Medicine/Dermatology, UW Medicine South Lake Union) to study UV-induced DNA damage responses, skin carcinogenesis, small-molecule inhibitors of the ATR pathway, and CRISPR-Cas9-based epigenome editing. The goals of these studies are to elucidate molecular mechanisms by which cells sense UV-induced DNA lesions (CPD and 6-4PP) and activate biological processes such as ATR-Chk1 checkpoint signaling, DNA repair, and mutagenic translesion synthesis and to dissect the molecular mechanisms by which caffeine prevents multiple types of skin cancers. Also, we will elucidate a mechanism of action of
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