Research - Laboratory/Non-Laboratory, Staff/Administrative
As a UW employee, you have a unique opportunity to change lives on our campuses, in our state and around the world. UW employees offer their boundless energy, creative problem solving skills and dedication to build stronger minds and a healthier world. UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits and natural beauty. All of which has allowed the UW to be nationally recognized as a "Great College to Work For" for four consecutive years.The Department of Immunology has grown to include 33 faculty, ~30 graduate students and more than 70 post-doctoral trainees. We are a strongly interactive group and share the view that the immune system provides an unparalleled platform from which to study processes common to all of mammalian biology, processes unique to host defense, and processes of clear and immediate importance to the understanding and amelioration of human disease.The Gerner Lab in the Department of Immunology at the UW School of Medicine has an excellent opportunity for an Imaging Data Scientist (Research Scientist 4).Research in the Gerner lab uses advanced microscopy technologies, such as multi-parameter confocal imaging and intravital 2-photon microscopy to study the development of immune responses to vaccination, infection, or during cancer. The Imaging Data Scientist will develop novel methods for in situ analysis of gene expression, in vivo cell photoconversion, or multiparameter image analysis, which will collectively allow a better understanding of how cellular positioning in tissues influences gene expression and cellular function. These new tools and findings will promote a better understanding of immune response generation in vivo, as well as advance biomedical technology development.Responsibities:Technology Development and Experimentation: (70%)Independently develop or incorporate existing methods for in situ analysis of gene expression, in vivo photoconversion, and/or multiparameter image analysis.Utilize these and other existing methods to study how cellular positioning in tissues influences gene expression and cell function. Methods may necessitate knowledge of programming (MATLAB, R), or using various imaging tools (ImageJ, Imaris). The lab uses multiplex confocal imaging and Histocytometry (10.1016/j.immuni.2012.07.011, 10.1016/j.immuni.2014.12.024, 10.1073/pnas.1708981114), as well as in vivo photoconversion (10.1126/science.aao4277) to identify localized cell events and study cellular gene expression based on tissue positioning.In collaboration with the research team, the incumbent will link how cellular positioning in tissues and exposure to localized microenvironment influences cellular gene expression. These findings will help reveal how tissue microanatomy influences immune cell heterogeneity and the downstream immune response.Data Analysis/Reporting, Data Presentation, and Scientific Manuscript Writing: (30%)Incumbent will regularly present their findings in lab meetings and departmental seminars and at professional conferences.Incumbent will be expected to published findings in peer-reviewed journals.The Imaging Data Scientist will work highly independently with regular oversight from the PI. The individual in this position may also help train and monitor the work of junior staff using the developed tools and will interact in a collaborative manner with other teams to accomplish overarching goals. The incumbent will provide ideas to the rest of the group to improve overall efficiency.Minimum Requirements:Ph.D. in Bioinformatics, Biotechnology, Immunology, or related field.At least two years of relevant experience, including experience with microscopy, bioinformatics, and analysis of gene expression. Relevant experience gained while in graduate school is acceptable.Desired:Programming skills, in vivo immunological assays, experience in image analysis.
Founded in 1861, the University of Washington is one of the oldest public institutions in the west coast and one of the preeminent research universities in the world. The University of Washington is a multi-campus university comprised of three different campuses: Seattle, Tacoma, and Bothell. The Seattle campus is made up of sixteen schools and colleges that serve students ranging from an undergraduate level to a doctoral level. The university is home to world-class libraries, arts, music, drama, and sports, as well as the highest quality medical care in Washington State and a world-class academic medical center. The teaching and research of the University’s many professional schools provide undergraduate and graduate students the education necessary toward achieving an excellence that will serve the state, the region, and the nation. As part of a large and diverse community, the University of Washington serves more students than any other institution in the Northwest.