Research - Laboratory/Non-Laboratory, Staff/Administrative
As a UW employee, you have a unique opportunity to change lives on our campuses, in our state and around the world. UW employees offer their boundless energy, creative problem solving skills and dedication to build stronger minds and a healthier world. UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits and natural beauty. All of which has allowed the UW to be nationally recognized as a "Great College to Work For" for four consecutive years.The fields of research for this position are protein engineering, purification and characterization. For more detailed information about the Institute for Protein Design please see http://www.ipd.uw.edu/About the Institute for Protein Design:The Institute for Protein Design (IPD) at the University of Washington in Seattle is creating a new world of synthetic proteins to address 21st-century challenges in medicine, energy, and technology. The IPD is a unique interdisciplinary environment where world-class researchers with expertise in computing and software, biochemistry, genome sciences, biological structure, pharmacology, immunology and other basic science disciplines, as well as clinical medicine, work together to both computationally design and experimentally characterize novel biomolecules. Current projects include the design of novel therapeutics for cancer, neurological diseases, and more, as well as new vaccines, nanomaterials, and enzymes.The UW Institute for Protein Design currently has an outstanding opportunity for a Research Scientist 3 (RS3) to serve as the leader for in vivo small animal studies at the Institute for Protein Design (IPD). This Preclinical Research Scientist will provide a core competency in in vivo animal models at the IPD, thereby fulfilling a growing demand for the evaluation of the functional characteristics of designed proteins in vivo. The Preclinical Research Scientist will be assigned work under general guidance and receive instruction on specific assignment objectives, complex features, and possible solutions. Guidance on unusual problems will be provided to the Preclinical Research Scientist by IPD Faculty, other UW Faculty, or animal facilities employees who are experts in animal models, and work shall be reviewed for application of sound professional judgment.The Preclinical Research Scientist will serve as the lead scientist in the IPD's In Vivo Core lab, having oversight of collaborative preclinical in vivo research using small animal models to assess biodistribution, pharmacokinetics, safety, efficacy, and immunogenicity of computationally designed proteins and immunogens. This position will perform professional work in support of scientific research evaluating the characteristics of designed proteins in vivo in common small animal models.In this role, ~60% of the effort will be dedicated to performing preclinical research evaluating the characteristics of designed proteins in vivo in common small animal models. Another ~30% of effort will be dedicated to coordinating study designs and communicating the results and interpretations of each study with a number of internal collaborators at the IPD and in some cases external collaborators at other institutions.The remaining ~10% of effort will be dedicated to continuous improvement of the In Vivo Core lab operations and standard operating procedures and interfacing with UW veterinary service personnel and the Office of Animal Welfare (OAW).Minimum Requirements:Master's Degree in Biochemistry + 3 or more years of experience in related field.The ideal Preclinical Research Scientist candidate will be someone who (i) selects and applies standardized scientific procedures and techniques to assignments of moderate to high complexity, involving potentially conflicting design requirements, (ii) continually learns and develops new in vivo methods and study designs, (iii) can manage individual research projects that they own, (iv) can provide timely and professional scientific services to a number of internal collaborators on several different projects, (v) can perform in vivo studies of novel molecules in a safe and humane manner, (vi) and enjoys interacting with other scientists in a highly collaborative and fast-paced work environment .Desired:Excellent knowledge of small animal biology and immunology and experience in conducting exploratory research using xenograft or syngeneic tumor models and humanized mouse models is highly preferred.Significant hands-on experience with mouse and rat models and their application in evaluating anti-cancer therapies, immunotherapeutics, or vaccines is highly desired.Experience with immunological readouts and their translation into early clinical trials is highly desirable.Familiarity with drug discovery is a plus.The ability to flourish in a highly matrixed organization and work well within multidisciplinary teams is desirable.Application Process:The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select "Apply to this position". Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your "My Jobs" page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
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