The Radionuclide Production and Molecular Radiotherapy Research Laboratories led by Dr. D. Scott Wilbur in the Department of Radiation Oncology at the University of Washington (Seattle, WA) develops and evaluates radiochemistry methods that can be applied to produce and purify therapeutic and theranostic radionuclides, as well as radiolabeling reagents/chelators for attaching radionuclides to biological targeting molecules, such as monoclonal antibodies for cancer therapy. The research conducted is primarily funded by the U.S. Department of Energy and the National Institutes of Health. All of the research efforts are collaborative in nature, spanning from therapeutic/theranostic radionuclide production to clinical trials evaluating new radioimmunotherapy agents.
A Postdoctoral/Senior Fellow position is now open. The position has a focus on the production of radionuclides for use in development of new radiopharmaceuticals. The successful candidate will participate in production, isolation, and quality control of radionuclides of interest (e.g., Se-72 and Re-186). Depending on the progress of the research, radionuclides might be produced for shipment to other U.S. investigators who have ordered through the Department of Energy's National Isotope Development Center (NIDC). Production of radionuclides will be conducted using the UW Medical Cyclotron Facility. The Senior Fellow is also expected to assist in the routine production of astatine-211 (211At). The 211At production will involve cyclotron irradiation of a bismuth target followed by wet chemistry isolation and purification. Some involvement in other aspects of radiopharmaceutical development studies can be expected. This position is a twelve month service period with an anticipated start date of 7/1/19.
1. Work with personnel in UW Medical Cyclotron Facility to determine methods for production of radionuclides of interest using the capabilities of the Scanditronix MC50 cyclotron
2. Prepare targets for irradiations to produce radionuclides of interest
3. Determine production rate, specific activity, and radioisotopic/radionuclidic purity
4. Following irradiations, retrieve irradiated targets from cyclotron vault and transport to Radionuclide Production Laboratory
5. Conduct radiochemical methods to isolate/purify (wet chemistry, distillations, chromatography, etc.) the radionuclide of interest
6. Conduct radiolabeling studies using the radionuclide produced and/or radionuclides obtained from other sources
7. Prepare radionuclide for shipment to other investigators at UW or other investigators for DOE's NIDC
8. Maintain/update standard operating procedures used in the production of radionuclides
9. Maintain an inventory of chemicals/radiochemicals and be responsible for the disposal of chemical/radiochemical waste
10. Write reports describing the production of radionuclides and progress on grant-funded projects involving radionuclides
11. Assist in grant writing and conduct grant and manuscript reviews as a learning process
12. Assist on other projects that the research team is working on an as-needed basis
The University of Washington and the International Union, Automobile, Aerospace and Agricultural Implement Workers of America, Local 4121 (UAW 4121) currently are negotiating their first collective bargaining agreement for Postdoctoral Scholars. Employees in this title are represented by UAW 4121 and will be subject to the applicable collective bargaining agreement, unless agreed exclusion criteria apply. For more information and updates on the bargaining process, please visit https://hr.uw.edu/labor/unions/uaw/postdoc-negotiation-updates.
Have obtained a Doctorate in Radiochemistry, Radiopharmaceutical Chemistry or other related basic science degrees
Have experience in working with radioactive materials, particularly unsealed radionuclides, and radioactivity detection equipment
Have experience with, and working knowledge of, radiochemical separation techniques, such as radiochromatography and extraction methods
Have experience with, and working knowledge of, radioanalytical methods, such as HPGe analysis
Be able to present and communicate research results at professional conferences
Have an ability to work independently and as part of a research team effort
Have a high interest in radiopharmaceutical sciences, being aware of the status of current and relevant science related to it
Have an understanding of radionuclide properties and importance in radiopharmaceutical development
Have familiarity with software important in radionuclide production, such as SRIM and EXFOR, and web sites such as the National Nuclear Data Center (NNDC)
Please submit your C.V., a brief statement of carrier interests, and names of 3 references to D. Scott Wilbur, Ph.D. (firstname.lastname@example.org) or Yawen Li, Ph.D. (email@example.com) by May 31, 2019.
Equal Employment Opportunity Statement
University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, sex, sexual orientation, marital status, pregnancy, genetic information, gender identity or expression, age, disability, or protected veteran status.
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